![]() ![]() ![]() ![]() Why have I paid 67 PER CENT tax on my savings interest? I earn over £100k but should at least get a £500 tax-free savings allowance.I became hooked on buying charity shop clothes - then left my husband for a man I'd just met.QUENTIN LETTS: The bloodiest mauling I’ve seen since our Patterdale terrier bit the Rector’s bottom.Body is found in the hunt for Clapham chemical attacker Abdul Ezedi: Met Police recover body in River Thames which they say is the 31-year-old suspect - nearly three weeks after mother and her children were attacked.Top police officer sacked for 'wholly misogynistic' behaviour which saw him 'demean and intimidate' female colleagues with sexual comments including pondering what one 'staff member's ponytail could be used for'.Woman who had her £30k Lexus UX stolen from her driveway in London claims police told her to 'go and pick it up herself' after she tracked it down.Diet that mimics the effect of fasting WITHOUT starving yourself could add years to followers' lives, trial shows.LIZ JONES: Why I've publicly shamed my former partners for over 25 years.Russia's Wagner group has rebranded under the shady spy chief behind Salisbury poisonings and is offering African 'regime survival packages' in return for access to natural resources, report finds.How much is YOUR council tax set to rise? Almost all local authorities are planning maximum 4.99% hike in April - £100 extra on an average Band D bill.Robin's X Factor ex Marcus Collins pays heartfelt tribute.Susanna Reid fights back tears as she announces death of Strictly star Robin Windsor on Good Morning Britain.Robin Windsor's haunting last posts: How Strictly Come Dancing star told followers he was 'hiding in the shadows' and hinted at 'trauma' in series of social media photos weeks before his shock death aged 44 - as devastated stars pay tribute. ![]()
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Posts related to FedEx / GLS, or shipping, must use the Shipping Megathread If your post is about shipping, FedEx, or GLS, you need to use the Shipping Megathread stickied at the top of the feed.ĭo not attempt to obfuscate your submission to bypass filtering We implement a variety of different automated filters to ensure that the rules are enforced effectively and fairly. Please do not impersonate another entity, claim to have insider knowledge when you do not, or provide intentional misinformation. No impersonation, claiming to have "insider knowledge", or posting intentional misinformation. ![]() Do note we require a minimum level of establishment, which is 10+ positive reviews/feedback within the last year as a seller, at the mod team's discretion. We will confirm our rules to you, which you'll need to accept to advertise at all here. ![]() For businesses selling accessories: please contact the mod team before making a post otherwise your post will be removed. Generic let's plays content is not allowed. Your first post in the sub may not be self-promotional in nature. Please ensure self-promotion is no more than 20% of your contributions. Keep self-promotion under 20% of your posts, and special rules for businesses selling accessories. The only exception that will be made will be for abandonware. This includes discussion of "grey area" posts like ROMs and cracked software. No links/discussion of illegal, copyrighted or pirated content Please do not discuss where to get, ask for, or share links to illegal, copyrighted or pirated content. If you want to hold a giveaway, please contact the mod-team first. We also do not allow non-reputable stores, auction sites and keyshops. No buying, selling, trading, begging, giveaways or crowd-funding. Posts must be about or related to the Steam Deck Posts must be on-topic and relevant to the Steam Deck (not just vaguely or tangentially related). Make it fun! However, the mod team reserves the right to remove Deck Flex posts at their discretion or change this rule at any time. But if you don't like this rule, please feel free to suggest other ideas rather than trolling the sub through harassing and ridiculous reports). Remember: Everyone is excited about their deck! But no one wants to see your confirmation email, shipping tracker, turned-off deck on a table, or a box literally ever. Show your deck in a unique setting, get creative with the photo, or add a funny/interesting caption. You CAN show off your deck (any time)!! Please flair these posts as "Deck Flex," and try to make your post engaging for others. No Photos of Boxes/Unboxing, no Screenshots of Order/Ship Emails. (This is a video game sub, for crying out loud.) Examples of content not allowed include but are not limited to: insults, hrassment, name calling, or trolling abuse of the report button because you do not like a post, a rule, an OP, or a mod 'Baiting' other users in to insults via trolling Being overly negative, condescending, argumentative, or mocking Slurs or insults of any kind Politics. Every example listed in this rule is an immediately bannable offense without warning, but this is not an exhaustive list. Don't be overly hostile or rude to other users. Keep the discussion civil and light, or your submission/comment will be removed. Official Website Frequently Asked Questions Steam Deck Discord Steam Deck Forum ProtonDB Rules:īe kind or Get Yeeted. ![]() Welcome to r/SteamDeck, the subreddit for Valve's handheld computer. ![]() ![]() ![]() Images take 295.0 kB which makes up the majority of the site volume. Only 10 of websites need less resources to load. This result falls beyond the top 1M of websites and identifies a large and not optimized web page that may take ages to load. Be kind, patient and offer great service and your group of dumb humans will happily transform into an army of smart ants. In fact, the total size of main page is 543.7 kB. When confronted with an angry mob it is easy to get intimidated by their numbers and the noise they produce. And what did we do? Not much except listen and stay polite. You can predict the rest: she turned into a loyal fan, removed her negative reviews and promoted us on all her social media accounts as the awesomest company ever. I told her to check her spam folder, where she found our email. I was just letting of some steam because I couldn’t find my password and your system isn’t sending me a new one’. She wrote ‘Oh hi, I didn’t expect you to actually read these emails. What happened and how can we make it right?’. But I swallowed my pride and replied ‘Sorry to hear our service let you down. Some sneer or veiled insult to make me feel better. ![]() My first instinct was to reply something mean and smart back. Then I received an email from her telling me that she wished we would all die, our company would burn down and for good measure she called me a few things I won’t repeat here. People were chiming in, there was talk of a denial of service attack and the angry mob was getting ready to storm the castle. She had left awful reviews about our company, left comments on every post on our blog telling us how awful our service was. Really.Ī few years ago I received an email from a customer. The trick of course is to remember that people are basically smart, and kind. Incur the wrath of the people and the web becomes a scary, dark and unforgiving place. Unfortunately sometimes these smart individuals seem to group together as an anonymous, unaccountable and aggressive mob. No other medium allows you to get as personal with your customers as the web. SmartyAnts Login Smarty Ants does not function without JavaScript enabled, please enable JavaScript and then refresh the page. Social media give you excellent access to individuals. Humans are smart as individuals but dumb as groupsĪs an online entrepreneur, website owner or even just someone with an online profile here at Linkedin you are dealing with both sides of the smart/dumb coin. But in groups they are dump and dangerous'.Īnts are dumb as individuals and smart as groups 'Well.' I started 'I guess that humans, as individuals, are smart. We talked about her plans for the evening and I warned her to avoid the crowds a bit. She is ten and she was going to visit a Lady Gaga concert that evening. I explained to her how one ant isn't all that smart, or powerful, but that ants as a community are very smart and powerful. Forgot your password Reset your password. Copies of BCSD’s Uniform Complaint policy, Sexual Harassment policy, and Nondiscrimination policies are available here and upon request.This week I was talking to my daughter about ants. If you believe you, or your student, have been subjected to discrimination, harassment, intimidation, or bullying you should contact your school site principal and/or the District’s Chief Compliance and Title IX Officer, Erin Johnston, by phone at (661) 631-4663, by email at or in person at 1300 Baker Street, Bakersfield, CA 93305. ![]() Not all bases of discrimination will apply to both education services and employment. BCSD prohibits discrimination, harassment, intimidation, and bullying in any employment practice, education program, or educational activity on the basis and/or association with a person or group with one or more of these actual or perceived characteristics of age, race or ethnicity, color, ancestry, nationality, national origin, immigration status, ethnic group identifications, religion, pregnancy, marital status, parental status, physical disability, mental disability, sex (including sexual harassment), sexual orientation, gender, gender identity, gender expression, medical information, genetic information, homelessness, foster status, military veteran status, political affiliation or any other basis prohibited by California state and federal nondiscrimination laws consistent with Education Code 200, 220 and 234.1, Penal Code 422.55, Government Code 11135, and Title IX. The ant updates the columns of i's routing table corresponding to all. The Bakersfield City School District (BCSD) is committed to equal opportunity for all individuals in education and in employment. Let i be a node visited by a smart ant on its way to its destination. ![]() ![]() As it is now, on the left is 1 Na, but on the right, there are 2 Na. To balance the above equation, which includes sodium and oxygen, this chemical equation must have the same amount of Na on the right side as well as on the left side. Typically, oxygen and hydrogen are balanced at the end. The most complex molecule will usually be balanced first. Trial and Error/Inspection method is used to balance simple chemical equations. ![]() We will balance the simple and complex equations with each method so that you can deeply understand the process of balancing chemical equations. We will use two methods to balance chemical equations here. The equation can be balanced by increasing the scalar number for every molecular formula. The same charge will exist on both sides of the unbalanced equation in case of net ionic reactions. Each side of the equation must, therefore, represent the same amount of each specific element. The quantity of each element does not change in a chemical reaction. You can reset your equation by clicking the "Reset" button. It will highlight the digits in blue color that it has added to balance the equation. The chemical reaction balancer will give you the balanced equation. After entering your equation in the input box, click the "Calculate" button. Enter the chemical equation that is unbalanced because a chemical balancer will show an error message if the given equation is already in a balanced form. Or you can write your equation in the input box. To use the chemical equation calculator, simply make your equations by clicking on the elements in the above periodic table. You don't have to write anything because everything can be done with simple clicks using this balanced equation calculator. You can also use number digits to specify the number of atoms for each element in your equation. You can click on any element, and it will automatically include that element in your equation. For your ease and comfort, we have provided an interactive periodic table. It is completely free of cost, and everyone can use it on the go. How to use balance equation calculator?īalancing equations calculator has a simple to use interface. We will discuss how you can use balancing chemical equations calculator and how to balance a chemical equation manually with a complete process. You don't have to rearrange the number of atoms manually for any equation from right now. ![]() ![]() Our equation balancer offers to balance your chemical equations on one click. If you are struggling to balance chemical equations as a student of chemistry, there is nothing to worry about, because we have got you covered. ![]() ![]() ![]() During this gap of school time instruction, it is critical that students continue to practice their newly obtained literacy skills and retain all of the information learned this year. With Smarty Ants, you can ensure every student in grades PreK-2 is on track for success from day one. Dear Parent, As the winter break approaches, I’d like to wish you and your family a happy and safe holiday break. With Smarty Ants, you can ensure every student in grades PreK-Grade 2 is on track. Second-grade students will read chapter books, build scripts, and record their lines in the virtual recording studio in preparation for the big show in the Greek Theatre at the end of each lesson. Microsoft Word - Winter Break letter.docx. The first step towards college and career literacy is foundational reading skills. Option 1: The teacher is able to first log into the Smarty Ants application with their e-mail address. Link BCSD Student Dashboard in Google Classroom. Students learn through fun, animated, game-like activities. ![]() Students, use this link to open the IBOSS. For help with your username and password, please contact your teacher. Sign in to your Office 365 account and access apps from the Office 365 portal, from the app launcher, or directly using the links below. Designed for all students in grades PreK-1, Smarty Ants® is an effective, research-driven solution that differentiates instruction and accelerates students on the path to foundational literacy all in an engaging, interactive, learning environment. Students, start connecting through Single Sign-On (SSO) to all of the apps you use in school. Students may use ClassLink to access the following District Curriculum Apps: Achieve 3000. Their ClassLink Dashboard will be the default web page. When logging into school computers, each student will use their mypolkschools account. Second-grade students will read chapter books, build scripts, and record their lines in the virtual recording studio in preparation for the big show in the Greek Theatre at the end of each lesson.Accelerate students toward mastery of foundational reading skills with Smarty Ants®.ĭesigned for all students in Grade 2, Smarty Ants® 2nd Grade is an effective, research-driven solution that differentiates instruction and accelerates students on the path to foundational literacy â all in an engaging, interactive, learning environment. The student login to Smarty Ants by using the information below. Smarty Ants is designed to build reading skills and accelerate learning in an engaging, interactive online learning environment. Accelerate students toward mastery of foundational reading skills with Smarty Ants®. This eliminates the need for a user to remember multiple usernames and passwords. ![]() Free for all Smarty Ants customers with an active account. The Smarty Ants 2nd Grade app expands access to the complete curriculum.Īccelerate students toward mastery of foundational reading skills with Smarty Ants®.ĭesigned for all students in Grade 2, Smarty Ants® 2nd Grade is an effective, research-driven solution that differentiates instruction and accelerates students on the path to foundational literacy – all in an engaging, interactive, learning environment. Designed for all students in grades PreK-1, Smarty Ants® is an effective, research-driven solution that differentiates instruction and accelerates students on the path to foundational literacy all in an engaging, interactive, learning environment. Option 1: The teacher can first log into the Smarty Ants application with their e-mail address (). ![]() ![]() ![]() Located atop a Benjamin Marshall-designed building at the corner of Astor and Division in Chicago’s Gold Coast is this 5,000-square-foot full floor penthouse available for the first time in 20 years. The $805 monthly HOA fees include water, parking, exercise facilities, and 24-hour door staff. The unit comes with a balcony as well as a large private terrace with decking and planters. The two-bedroom, two-bathroom condo with floating staircase is packed with character as brick, timber, and exposed ductwork fill the 11-foot-high interior space. While there have certainly been critiques on how well the show captures Chicago, I think everyone can agree that this duplex penthouse in Erie Center Lofts is pretty cool. River North is the setting of Hulu’s The Bear. Let’s take a look at these unquestionably impressive penthouses (especially the one in the Gold Coast) that are currently for sale. ![]() The following properties of differing architectural styles are in great locations all over the city. With various price points from $500,000 to over $4 million, it’s obviously not cheap to live high in the sky. In Chicago Apartments: A Century of Lakefront Luxury, Neil Harris wrote “the sparkle of Hollywood-inspired apartments…where high life characters moved through penthouses with enormous, high-ceilinged rooms and landscaped terraces” had a huge impact on how people viewed luxury living, especially in the inter-war period of the 1920s. Most people think of a top floor luxury apartment that offers first-rate city views. The word penthouse implies a certain air of elegance. ![]() ![]() ![]() ![]() I have more or less move to The dark Side now, i have removed my WB Win 10 SSD from my set up, as for me, it had too many issues for Win 11 and WB11 to work out of the box if i updated it. Our comments are relevant, as there has to be Balance in all things. Some users really go nuts over these older looking retro skins, but not me or you c242. I spend too long each day at my PC, and that was 100% why i got into WBs and Themes, so i would not have to look at the MS Gui. I know lots like all the old stuff and looks, but as i was a user of those OSs, for me, its a case of "Been There Done That" and i want to move forward and not back. I got into skinning and then Themes to bring my desktop to life, make it look out of this world. If critics on that release-politics (boring retro all over) is not allowed, this is not my place to stay. Note: If this again gets deleted like the last time I am gone. So instead of bringing modern designs that fully support darkmode we now have a myriad dead OSs mimiks that only look right in light mode? WB has no value to me anymore if I have to look at grey, light blue and white all over. And if you haven't tried WindowBlinds 11 yet, you can download a free trial here. You can also modify any existing theme from within the WindowBlinds app, too.Īs we continue to look for new themes to build for WindowBlinds 11, make sure to let us know in the comments what you would like to see land in our next release. If you already have WindowBlinds installed, you can directly download the skin here.ĭon’t forget: you can also create your own themes as well with our SkinStudio that comes bundled with every copy of WindowBlinds 11. To grab this specific theme, you can download and install the latest version of WindowBlinds 11. That’s the beauty of WindowBlinds, though: there are thousands of themes that you can apply to your desktop to make it a truly personalized experience. With a flatter design style and monochromatic elements, Mac Classic will certainly have its fans - but we know it’s not for everyone. In our latest theme for WindowBlinds, Mac Classic brings back a different sort of retro feel that lets you experience the unique Mac style from yesterday on your Windows 10 or 11 desktop today. In the same vein, we have created another new retro style that crosses the OS waters to MacOS. For fans of older versions of Windows, this is a great way to experience some of the late 90s style while retaining the modern features that Windows 11 provides. Late last year, we brought a new theme to WindowBlinds 11 that we call Windows Classic. ![]() Wikis Immerse yourself in game lore, tutorials, and more. Metaverse See how you rank against other players in your favorite games. Community Stay up-to-date with game news and dev journals. All Games Check out our complete catalog of award-winning games. Ashes of the Singularity Massive-scale warfare in an epic RTS. The Political Machine 2024 Win the hearts and minds of America's voters. Star Control The space action/adventure classic returns. Sins of a Solar Empire II Real-time strategy. Games Galactic Civilizations Discover new adventures and rule the galaxy your way in this 4X space strategy game. Corporate Software Solutions Increase productivity, design intelligent controls and reinforce branding with our enterprise products. View All Software Products Discover our productivity and customization tools. WindowBlinds 11 Customize the look and feel of your taskbar, window frames, and more. SpaceMonger Quickly free up storage space on PCs and shared-networks. CursorFX Customize your Windows cursor and create your own. Groupy 2 Organize multiple applications into grouped tabs on your Windows desktop. Multiplicity Connect multiple PCs with one keyboard and mouse. DeskScapes Personalize your desktop wallpaper with animated pictures and video. Fences 5 Automatically organize your desktop apps, files, and folders on Windows 10 and 11. ![]() Start11 Customize the Start Menu and Taskbar in Windows 10/11. Software Object Desktop Your complete Windows customization suite. ![]() ![]() Therefore, the increased p53 protein expression level in some cells after doxorubicin exposure is a response to doxorubicin-induced DNA damage. The complex enzyme is unable to relegate DNA strand breaks and thus, the DNA damage would be increased. Doxorubicin forms a stable complex with DNA and topoisomerase IIα resulting in inhabitation of the normal function of the enzyme. Doxorubicin is obtained from Streptomycespeucetius, and can also be commercially synthesized. Doxorubicin is a member of cytotoxic anthracyclin antibiotics, a group of antibiotics that is known to cause generations of intracellular superoxide and hydrogen peroxide, which can mediate mitochondrial damage and apoptosis in a p53-independent manner, also induces cytotoxicity in tumor cells by developing reactive oxygen. The drug is also used to treat a wide variety of solid tumors and hematological malignancies. Monotherapy with doxorubicin has a good response rate of 10% to 50%, and doxorubicin-containing combination therapies usually result in better survival rate. Doxorubicin (adriamycin) has been used to treat cancers for over 30 years and it is an effective therapy and is also considered as the most effective drug in treatment of breast cancer. Chemotherapy is frequently used to relieve symptoms in advanced breast cancer patients and to reduce the risk of recurrences for patients with localized breast cancer. However, coexpression of PTEN with p53 has less effects in facilitating its transactivation than with wild type p53. This indicates that the COOH terminus of p53 has an inhibitory effect on its function. It has been reported that p53 maintains the transactivation on its target genes however, it loses 90% of the ability to interact with PTEN. To further evaluate whether the interaction between PTEN and p53 is required for PTEN autoregulation, a p53 COOH-terminal deletion mutant has been generated. The physical interaction between PTEN and p53 is required for the transregulation of p53 with the PTEN expression and the phosphatase activities of PTEN are not necessary for the effect. PTEN increases p53 protein level directly by increasing the half-life of p53. PTEN has the ability to autoregulate its own expression and such autoregulation occurs through stabilizing p53. On the other hand, PTEN expression is regulated at the transcriptional level by a set of transcriptional factors, including the p53, and at the posttranscriptional level by protein localization, modification, and degradation. It is possible that the interaction between p53 and ER, resulting in their reciprocal regulations, plays an important role in adjusting normal breast epithelial cell proliferation and the aberration of this control may lead to breast cancer onsets and progressions. ![]() Increasing evidence indicates that p53 dysfunction is an important event in breast cancer. ![]() The p53 has the ability to regulate ERα expression. Estrogen and ER play important roles in genesis and malignant progression of breast cancer. Breast tumors expressing a high level of p53 are more frequently in estrogen receptor (ER) negative and are associated with a higher proliferation rate and poorer survival rates. Under normal cellular condition the p53 signaling pathway is in standby mode and its activation occurs in response to cellular stresses and leads to an increase in the level of p53 protein. The tumor suppressor protein p53 that is known as 'molecular policeman' has been identified as a key regulator of cell metabolism for its modulation of the balance between the glycolytic and mitochondrial respiratory pathways and regulate the cell cycle, inhibit angiogenesis and DNA repair and apoptosis. These included the p53 pathway in 90% of the cell lines (p53), the RB pathway in 64% (p16) and the PI3K pathway in 56% (PTEN). ![]() The first pattern involved frequent mutations among the cell lines in genes from the same tumor suppressor pathway. Compilation of the mutation data revealed two prevalent gene mutation patterns among the breast cancer cell lines (SKBR3 and T47D). ![]() Breast cancer is the second leading cause of cancer-related deaths in women. ![]() ![]() It’s not only a platform for an older demographic, however, it’s also a great platform if your business sells to consumers. So it’s no surprise that you can target by just about any of these facets.įacebook has users of all ages but is particularly popular among older users - great news for advertisers who have struggled to appeal to this demographic. Facebook has loads of data points on each of its users - what groups you are a part of, everything in your profile, your interests, etc. Setting aside the massive amount of daily active users on Facebook and Instagram, these two platforms are a better choice for your social media marketing because of the sheer amount of targeting options. Simply put, these two platforms are without a doubt worth your ad spend if you are a business trying to market your products or services online. A massive ROI like that is absolutely worth it, not to mention research that backs up a higher clickthrough rate, conversion rate, and a significantly lower cost-per-conversion as well.įrom significant increases in followers to improved purchasing intent to a huge reach to the simple fact that ads are more subtle and less invasive on the platform in general, Instagram ads make up for being a bit pricier with their unparalleled results. Many advertisers have seen a return on investment (ROI) of anywhere from 4-8x as much as they put into their campaign. In reality, though, this couldn't be further from the truth. Your assumption might be that Facebook would be a less successful place to run ads just because of the competition. Because of the billions of users on Facebook and Instagram worldwide, there's a very real chance for posts to garner hundreds of thousands of reactions and even more impressions.Īdvertising on Facebook and Instagram is not only worth it, but a necessity (nowadays) for most businesses to market their products or services. From gorgeous photos to personal videos to humorous GIFs, Facebook and Instagram thrive on their visual aids. Not to mention, just from the sheer volume of users, you have the ability to reach the largest target audience on Facebook and Instagram - it’s estimated that the average user spends about 2 hours a day on both platforms combined.įacebook and Instagram have an advantage over other platforms because of their incredibly visual nature. Plus, with so many celebrities, public figures, and notable people to be found on Facebook and Instagram, there's undoubtedly appeal. While you can certainly befriend and follow more serious users who offer the kind of professional content you're likely to find on LinkedIn, these two platforms are, by and large, a place for normal, everyday people to interact with one another. Facebook and Instagram are social media platforms that appeal to a wide net of people - this might explain why there are nearly three billion active users on the former and over one billion active users on the latter. ![]() |
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